Son Güncelleme:

21/08/2020 - 16:40

Üniversitemiz akademisyenleri Arş. Gör. Ali Deniz Dalgıç, Prof. Dr. Dilek Şendil Keskin ve Prof. Dr. Zafer Evis’in yazarları arasında bulunduğu “Structural and Biological Analysis of Mesoporous Lanthanum Doped βTCP For Potential Use as Bone Graft Material” başlıklı makale Materials Today Communications’ta yayınlandı.

In this study, mesoporous particles of β-tricalcium phosphate (βTCP, βCa3(PO4)2) and lanthanum (La) doped βTCP were synthesized using wet precipitation method attached with microwave refluxing system. The obtained materials were characterized and analysed using different sort of techniques such; X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), Inductively coupled plasma optical emission spectroscopy (ICP-OES), Brunauer–Emmett–Teller (BET) and helium pycnometer. With incorporation of La3+ ions, relevant expansion in lattice parameters of βTCP crystal was observed along with inhibition growth rate was observed. βTCP and La- βTCP materials were mesoporous in nature, pore diameter and pore volume were expanded with incorporation of La3+ ions. The loading /release on βTCP and La- βTCP particles surfaces were evaluated using fetal bovine serum (FBS) proteins. In vitro cell culture studies were performed with human osteosarcoma cell line (Saos-2). The outcomes approved that all La-βTCP materials were cytocompatible and strict dose dependent effect of La3+ ions was observed on cell viability and alkaline phosphatase (ALP) activity. These results strongly suggest that La-βTCP materials have a potential application in bone tissue engineering.


Motameni, A., Dalgic, A. D., Alshemary, A. Z., Keskin, D., & Evis, Z. (2020). Structural and biological analysis of mesoporous lanthanum doped βTCP for potential use as bone graft material. Materials Today Communications, 23 doi:10.1016/j.mtcomm.2020.101151

 

Makaleye erişim için: https://www.sciencedirect.com/science/article/pii/S2352492820311284


ODTÜ Yazarları

Arş. Gör. Ali Deniz Dalgıç

Web of Science/Publons Araştırmacı Kimliği: K-3623-2017
alideniz@metu.edu.tr Scopus Yazar Kimliği: 57193756153
Yazar Hakkında ORCID: 0000-0003-2904-1204

Prof. Dr. Dilek Şendil Keskin

dkeskin@metu.edu.tr Scopus Yazar Kimliği: 36967297400
Yazar Hakkında

Prof. Dr. Zafer Evis

evis@metu.edu.tr Scopus Yazar Kimliği: 14070067300
Yazar Hakkında ORCID: 0000-0002-7518-8162

Etiketler/Anahtar sözcükler:

Bone graft materials, In vitro degradation, Lanthanum, Mesoporous particles, β-Tricalcium phosphate


Diğer Yazarlar:
Motameni, A. (ODTÜ) & Alshemary, A. Z.